![]() ![]() ![]() Diagnostic criteria for the electrophoretic patterns of serum and urinary proteins in multiple myeloma. ![]() Role of 18F-FDG PET/CT in the diagnosis and management of multiple myeloma and other plasma cell disorders: A consensus statement by the International Myeloma Working Group. International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma. Remission of disseminated cancer after system oncolytic virotherapy. Plasma cell neoplasms (including multiple myeloma) treatment (PDQ) - Patient version.As myeloma cells crowd out normal blood cells, multiple myeloma can also cause anemia and other blood problems. Multiple myeloma may cause problems with kidney function, including kidney failure. Single-unit muscle has its muscle fibers joined by gap junctions so that the muscle contracts as a single unit. Multiple myeloma can also affect your bones, leading to bone pain, thinning bones and broken bones. Myeloma cells inhibit your body's ability to fight infections. Multiple myeloma almost always starts out as MGUS, so having this condition increases your risk.Ĭomplications of multiple myeloma include: Personal history of a monoclonal gammopathy of undetermined significance (MGUS).If a brother, sister or parent has multiple myeloma, you have an increased risk of the disease. Black people are more likely to develop multiple myeloma than are people of other races. Men are more likely to develop the disease than are women. Your risk of multiple myeloma increases as you age, with most people diagnosed in their mid-60s. Risk factorsįactors that may increase your risk of multiple myeloma include: However, in MGUS, the levels of M proteins are lower and no damage to the body occurs. MGUS, like multiple myeloma, is marked by the presence of M proteins - produced by abnormal plasma cells - in your blood. Multiple myeloma almost always starts out as a relatively benign condition called monoclonal gammopathy of undetermined significance (MGUS). Cancer cells can also cause damage to the bones that increases the risk of broken bones. Instead, the abnormal antibodies (monoclonal proteins, or M proteins) build up in the body and cause problems such as damage to the kidneys. The myeloma cells continue trying to produce antibodies, as healthy plasma cells do, but the myeloma cells produce abnormal antibodies that the body can't use. In the bone marrow, myeloma cells crowd out healthy blood cells, leading to fatigue and an inability to fight infections. The abnormal cell multiplies rapidly.īecause cancer cells don't mature and then die as normal cells do, they accumulate, eventually overwhelming the production of healthy cells. Doctors know that myeloma begins with one abnormal plasma cell in your bone marrow - the soft, blood-producing tissue that fills in the center of most of your bones. ![]()
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